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Endocrine disruptors and reproductive toxicology: a molecular approach
Boleas, S.; Ryningen, A.; Fluge, Ø.; Lillehaug, J.; Goksøyr, A. (2000). Endocrine disruptors and reproductive toxicology: a molecular approach, in: Norberg, B. et al. (Ed.) Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. pp. 381
In: Norberg, B. et al. (2000). Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. International Symposium on the Reproductive Physiology of Fish, 6. Department of Fisheries and Marine Biology, University of Bergen: Bergen. ISBN 82-7461-048-2. 499 pp., meer
In: International Symposium on the Reproductive Physiology of Fish. Museo Nacional de Ciencias Naturales. , meer
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  • Boleas, S.
  • Ryningen, A.
  • Fluge, Ø.
  • Lillehaug, J.
  • Goksøyr, A.
Abstract
    Current research on biomarkers for endocrine disruption in fish focuses on the use of key proteins (vitellogenin or zona radiata proteins) as biomarkers for exposure to chemicals with estrogenic effects. Our main interest is to understand the molecular basis of endocrine disruption, searching for genes that are differentially expressed when fish populations are exposed to xenoestrogens. In this study, a replica colony screening strategy was developed and used to study the differential transcription of genes in nonylphenol-exposed fish. This strategy may identify differentially expressed genes, which may be interesting for elucidating the mechanisms behind these responses and for the development of new biomarkers for endocrine disrupting compounds
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