Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
Di Dato, V.; Di Costanzo, F.; Barbarinaldi, R.; Perna, A.; Ianora, A.; Romano, G. (2019). Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome. NPG Scientific Reports 9(1): 14 pp. https://dx.doi.org/10.1038/s41598-019-46276-8
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, meer
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| Trefwoord |
Thalassiosira rotula Meunier, 1910 [WoRMS]
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| Auteurs | | Top |
- Di Dato, V.
- Di Costanzo, F.
- Barbarinaldi, R.
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- Perna, A.
- Ianora, A.
- Romano, G.
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| Abstract |
Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world’s oceans and are responsible for 20–25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthetic pathways that potentially lead to the synthesis of interesting secondary metabolites with pharmaceutical applications such as polyketides, prostaglandins and secologanin. We also show that these pathways are differentially expressed in conditions of silica depletion in comparison with standard growth conditions. |
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