Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia
Dal Piaz, F.; Bader, A.; Malafronte, N.; D'Ambola, M.; Petrone, A.M.; Porta, A.; Ben Hadda, T.; De Tommasi, N.; Bisio, A.; Severino, L. (2018). Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia. Phytochemistry 155: 191-202. https://dx.doi.org/10.1016/j.phytochem.2018.08.003
In: Phytochemistry. PERGAMON-ELSEVIER SCIENCE LTD: Oxford. ISSN 0031-9422; e-ISSN 1873-3700, meer
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| Auteurs | | Top |
- Dal Piaz, F.
- Bader, A.
- Malafronte, N.
- D'Ambola, M.
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- Petrone, A.M.
- Porta, A.
- Ben Hadda, T.
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- De Tommasi, N.
- Bisio, A.
- Severino, L.
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| Abstract |
The surface extract of an accession of Psiadia punctulata (DC.) Vatke (Asteraceae) growing in Saudi Arabia was investigated for its phytochemicalcomposition. A bio-guided investigation of the extract led to the isolation of thirteen ent-kaurane and trachylobane diterpenes and seventeen compounds previously described, including nine flavonoids and eight diterpenes. Three flavonoids and one ent-kaurane diterpene showed antimicrobial activity with MIC100 values ranging from 25 to 150 μg/ml. The extract showed antibacterial activity against Staphylococcus aureus (MIC100 = 180 μg/ml) and antifungal activity against Candida albicans (MIC0 = 130 μg/ml). The isolated 3′,4′,5,7-tetramethoxyflavone, at a concentration of 40 μg/ml, displayed the ability to reduce biofilm formation of S. aureus and C. albicans by 50% and 90% respectively. |
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