Marine actinomycetes in biodiscovery
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| Auteurs | | Top |
- Kurtböke, D.I.
- Grkovic, T.
- Quinn, R.J.
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| Abstract |
Marine natural products will be the driving force for interdisciplinary advancements bridging medicine, chemistry, and biology for sustainable future biotechnological advancements. Recent advances in sequencing technology and bioinformatics have revealed that actinomycete genomes encode far more secondary metabolite gene clusters than originally thought. The development of new culturing techniques from marine environments has enabled the isolation of previously uncultured actinomycetes resulting in the identification of new bioactive compounds deriving from these bacteria, including species-specific bioactive compounds. Advances in genomic technologies have renewed interest in marine actinomycetes as an attractive source of new therapeutic agents. Genome sequences of bioactive marine actinomycete taxa will continue to provide information on the bioactive potential of the genus/family members, and selective isolation protocols will be designed based on the taxon-specific information generated. This chapter provides an overview on the above highlighted advances from an eco-taxonomical perspective reflecting on the diversified natural product chemistry provided by marine actinomycetes. |
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