Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect
Ounnas, F.; de Lorgeril, M.; Salen, P.; Laporte, F.; Calani, L.; Mena, P.; Brighenti, F.; Del Rio, D.; Demeilliers, C. (2017). Rye polyphenols and the metabolism of n-3 fatty acids in rats: a dose dependent fatty fish-like effect. NPG Scientific Reports 7(40162): 7 pp. http://dx.doi.org/10.1038/srep40162
In: Scientific Reports (Nature Publishing Group). Nature Publishing Group: London. ISSN 2045-2322; e-ISSN 2045-2322, meer
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| Auteurs | | Top |
- Ounnas, F.
- de Lorgeril, M.
- Salen, P.
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- Laporte, F.
- Calani, L.
- Mena, P.
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- Brighenti, F.
- Del Rio, D.
- Demeilliers, C.
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| Abstract |
As long-chain fatty acids (LCFA) of the n-3 series are critically important for human health, fish consumption has considerably increased in recent decades, resulting in overfishing to respond to theworldwide demand, to an extent that is not sustainable for consumers’ health, fisheries economy, and marine ecology. In a recent study, it has been shown that whole rye (WR) consumption improves bloodand liver n-3 LCFA levels and gut microbiota composition in rats compared to refined rye. The present work demonstrates that specific colonic polyphenol metabolites may dose dependently stimulate thesynthesis of n-3 LCFA, possibly through their microbial and hepatic metabolites in rats. The intake of plant n-3 alpha-linolenic acid and WR results in a sort of fatty fish-like effect, demonstrating that the n-3 LCFA levels in blood and tissues could be increased without eating marine foods, and therefore without promoting unsustainable overfishing, and without damaging marine ecology. |
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