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A radiation hybrid map of the European sea bass (Dicentrarchus labrax) based on 1581 markers: Synteny analysis with model fish genomes
Guyon, R.; Senger, F.; Rakotomanga, M.; Volckaert, F.A.M.; Hitte, C.; Galibert, F. (2010). A radiation hybrid map of the European sea bass (Dicentrarchus labrax) based on 1581 markers: Synteny analysis with model fish genomes. Genomics (S. Diego Calif.) 96(4): 228-238. http://dx.doi.org/10.1016/j.ygeno.2010.07.007
In: Genomics (San Diego, Calif.). Elsevier: San Diego. ISSN 0888-7543; e-ISSN 1089-8646, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoorden
    Dicentrarchus labrax (Linnaeus, 1758) [WoRMS]
    Marien/Kust
Author keywords
    Sea bass; RH-panel; Mapping; Synteny; Comparative genomics
Auteurs  Top 
  • Guyon, R.
  • Senger, F.
  • Rakotomanga, M.
  • Volckaert, F.A.M., meer
  • Hitte, C.
  • Galibert, F.
Abstract
    The selective breeding of fish for aquaculture purposes requires the understanding of the genetic basis of traits such as growth, behaviour, resistance to pathogens and sex determinism. Access to well-developed genomic resources is a prerequisite to improve the knowledge of these traits. Having this aim in mind, a radiation hybrid (RH) panel of European sea bass (Dicentrarchus labrax) was constructed from splenocytes irradiated at 3000 rad, allowing the construction of a 1581 marker RH map. A total of 1440 gene markers providing ~ 4400 anchors with the genomes of three-spined stickleback, medaka, pufferfish and zebrafish, helped establish synteny relationships with these model species. The identification of Conserved Segments Ordered (CSO) between sea bass and model species allows the anticipation of the position of any sea bass gene from its location in model genomes. Synteny relationships between sea bass and gilthead seabream were addressed by mapping 37 orthologous markers. The sea bass genetic linkage map was integrated in the RH map through the mapping of 141 microsatellites. We are thus able to present the first complete gene map of sea bass. It will facilitate linkage studies and the identification of candidate genes and Quantitative Trait Loci (QTL). The RH map further positions sea bass as a genetic and evolutionary model of Perciformes and supports their ongoing aquaculture expansion.
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