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Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges
Helyar, S.J.; Hemmer-Hansen, J.; Bekkevold, D.; Taylor, M.I.; Ogden, R.; Limborg, M.T.; Cariani, A.; Maes, G.E.; Diopere, E.; Carvalho, G.R.; Nielsen, E.E. (2011). Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges. Mol. Ecol. Resour. 11(Supplement s1): 123-136. dx.doi.org/10.1111/j.1755-0998.2010.02943.x
In: Molecular Ecology Resources. Blackwell Publishing: Oxford. ISSN 1755-098X; e-ISSN 1755-0998, meer
Peer reviewed article  

Beschikbaar in  Auteurs 
    VLIZ: Open Repository 222170 [ OMA ]

Trefwoorden
    Bias (Statistics)
    Biology > Genetics > Population genetics
    Population characteristics > Population structure
    Software
    Marien/Kust
Author keywords
    ascertainment bias; nonneutral loci; outlier detection; population genomics; population structure; software

Auteurs  Top 
  • Helyar, S.J.
  • Hemmer-Hansen, J.
  • Bekkevold, D., meer
  • Taylor, M.I.
  • Ogden, R.
  • Limborg, M.T.
  • Cariani, A., meer
  • Maes, G.E., meer
  • Diopere, E., meer
  • Carvalho, G.R.
  • Nielsen, E.E.

Abstract
    Recent improvements in the speed, cost and accuracy of next generation sequencing are revolutionizing the discovery of single nucleotide polymorphisms (SNPs). SNPs are increasingly being used as an addition to the molecular ecology toolkit in nonmodel organisms, but their efficient use remains challenging. Here, we discuss common issues when employing SNP markers, including the high numbers of markers typically employed, the effects of ascertainment bias and the inclusion of nonneutral loci in a marker panel. We provide a critique of considerations specifically associated with the application and population genetic analysis of SNPs in nonmodel taxa, focusing specifically on some of the most commonly applied methods.

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