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The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels
Geffeney, S.L.; Ruben, P.C. (2006). The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels. Mar. Drugs 4(3): 143-156. https://dx.doi.org/10.3390/md403143
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, meer
Peer reviewed article  
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Trefwoorden
    Materials > Hazardous materials > Biological poisons > Neurotoxins
    Materials > Hazardous materials > Biological poisons > Tetrodotoxin
    TTX
    Marien/Kust
Auteurs  Top 
  • Geffeney, S.L.
  • Ruben, P.C.
Abstract
    Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
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