Ciguatera poisoning trace-back in Europe leads to a novel ciguatoxin-3C group characterization from the Indian Ocean
Loeffler, C.; Spielmeyer, A.; Blashke, V.; Bodi, D.; Kappenstein, O. (2022). Ciguatera poisoning trace-back in Europe leads to a novel ciguatoxin-3C group characterization from the Indian Ocean. Research Square 1715170/v1: 1-20. https://dx.doi.org/10.21203/rs.3.rs-1715170/v1
In: Research Square (Preprints). Research Square: Durham. ISSN 2693-5015, more
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Document type: Preprint
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Ciguatera outbreak; fish poisoning; ciguatoxin; LC-MS/MS; Neuro-2a; human health |
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- Loeffler, C.
- Spielmeyer, A.
- Blashke, V.
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| Abstract |
The consumption of seafood containing marine biotoxins called ciguatoxins (CTXs) can result in ciguatera poisoning (CP), a globally prevalent seafood-born human illness. Since 2015 isolated and mass outbreaks of CP have occurred along the southwestern coast of India, however, no attributable CTXs have yet been identified. Herein, several CTXs are described in an often marketed snapper species (Lutjanus bohar) from southwest India. CTX3C-group compounds were identified by LC-MS/MS with a toxicity range of 0.79-5.39 ng CTX3C equivalent (eq.) g-1 wet tissue eq., as determined by an in vitro cell (Neuro-2a) assay. Samples investigated were part of a 7,000 kg international shipment of frozen snapper product imported into the European Union and subsequently implicated in a 2020 CP outbreak in the Netherlands. The identification of CTX3C-group toxins in fish originating from coastal India suggests a re-evaluation of the current understanding of CTXs associated CP with seafood from the Indian Ocean region. |
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