Synaptic transmission in the squid stellate ganglion
Llinás, R.; Sugimori, M. (1995). Synaptic transmission in the squid stellate ganglion, in: Abbott, N.J. et al. (Ed.) Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish. pp. 254-270
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| Abstract |
Our understanding of the mechanism responsible for depolarization-release coupling at chemical junctions has advanced quite steadily over the last three decades, much of it directly due to the study of the giant synapse in the squid stellate ganglion. From such work, general agreement has been reached regarding several aspects of synaptic transmission: i) Presynaptic membrane depolarization, the most common triggering signal for release, is achieved by an influx of calcium into the presynaptic terminal. ii) Synaptic transmitter is released from specialized sites characterized by the confluence of an intracellular calcium concentration ([Ca²+]i) increase, the biochemical cascade triggered by the calcium, and the intracellular organelles involved in this secretory event. iii) The localization of the intracellular calcium concentration microprofiles that follow voltage-dependent calcium-channel activation is a critical parameter in ensuring that the set of events triggering release occurs with sufficient speed to guarantee a short synaptic delay. |
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