Marine actinobacterial metabolites and their pharmaceutical potential
Manivasagan, P.; Venkatesan, J.; Sivakumar, K.; Kim, S-K. (2015). Marine actinobacterial metabolites and their pharmaceutical potential, in: Kim, S.-K. Springer handbook of marine biotechnology. pp. 1371-1386. https://dx.doi.org/10.1007/978-3-642-53971-8_63
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| Keywords |
Prokaryotes > Microorganisms > Bacteria > Firmicutes > Actinomycetales > Actinoplanaceae > Actinoplanes
Prokaryotes > Microorganisms > Bacteria > Firmicutes > Actinomycetales > Pseudonocardiaceae > Saccharopolyspora
Prokaryotes > Microorganisms > Bacteria > Firmicutes > Actinomycetales > Streptomycetaceae > Streptomyces
Amycolatopsis (Lechevalier, Prauser, Labeda & Ruan, 1986) emend. Lee, 2009 [WoRMS]; Micromonospora Orskov, 1923 [WoRMS]
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| Authors | | Top |
- Manivasagan, P.
- Venkatesan, J.
- Sivakumar, K.
- Kim, S-K.
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| Abstract |
Marine actinobacteria are one of the most efficient groups of secondary metabolite producers and are very important from a pharmaceutical industry point of view. Among its various genera, Streptomyces, Saccharopolyspora , Amycolatopsis , Micromonospora , and Actinoplanes are the major producers of commercially important biomolecules. Several species have been isolated and screened from soil in the past decades. Consequently, the chance of isolating a novel actinobacteria strain from a terrestrial habitat, which would produce new biologically active metabolites, has been reduced. The most relevant reason for discovering novel secondary metabolites is to circumvent the problem of resistant pathogens, which are no longer susceptible to the currently used drugs. Existence of actinobacteria has been reported in the hitherto untapped marine ecosystem. Marine actinobacteria are efficient producers of new secondary metabolites that show a range of biological activities including antibacterial, antifungal, anticancer, antitumor, cytotoxic activities , etc. Bioactive compounds from marine actinobacteria possess distinct chemical structures that may form the basis for the synthesis of new drugs that could be used to combat resistant pathogens. |
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