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Enzymatically synthesized biosilica
Wang, X.; Schröder, H.C.; Müller, W.E.G. (2015). Enzymatically synthesized biosilica, in: Kim, S.-K. Springer handbook of marine biotechnology. pp. 1265-1277. https://dx.doi.org/10.1007/978-3-642-53971-8_57
In: Kim, S.-K. (2015). Springer handbook of marine biotechnology. Springer-Verlag Berlin Heidelberg: Berlin. ISBN 978-3-642-53970-1. XLVI, 1512 pp. https://dx.doi.org/10.1007/978-3-642-53971-8, more
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  • Wang, X.
  • Schröder, H.C.
  • Müller, W.E.G.
Abstract
    Structural biomaterials are hierarchically organized and biofabricated. Biosilica represents the main mineral component of the sponge skeletal elements, the spicules. We summarize recent data on the different levels of molecular, biological, and structural hierarchies controlling the synthesis of the picturesquely and intricately architectured spicules/skeletons. Biosilica is a promising material/substance for the amelioration and/or treatment of human bone diseases and dysfunctions. It has been demonstrated that biosilica causes in vitro, a differential effect on the expression of the genes OPG (osteoprotegerin) and RANKL (ligand of the receptor activator of NF-κB), as well as induces the expression of the key mediator BMP -2 (bone morphogenetic protein 2); they are promising candidates for treatment of osteoporosis.
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