Glucocorticoids inhibit the expression of estrogen receptor (rtER) and vitellogenin (rtVg) in the liver of rainbow trout
Lethimonier, C.; Flouriot, G.; Tujague, M.; Valotaire, Y.; Kah, O.; Ducouret, B. (2000). Glucocorticoids inhibit the expression of estrogen receptor (rtER) and vitellogenin (rtVg) in the liver of rainbow trout, in: Norberg, B. et al. (Ed.) Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. pp. 285-288
In: Norberg, B. et al. (2000). Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. International Symposium on the Reproductive Physiology of Fish, 6. Department of Fisheries and Marine Biology, University of Bergen: Bergen. ISBN 82-7461-048-2. 499 pp., more
In: International Symposium on the Reproductive Physiology of Fish. Museo Nacional de Ciencias Naturales. , more
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| Authors | | Top |
- Lethimonier, C.
- Flouriot, G.
- Tujague, M.
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- Valotaire, Y.
- Kah, O.
- Ducouret, B.
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| Abstract |
The effects of cortisol on the hepatic expression of rainbow trout estrogen receptor (rtER) and vitellogenin (rtVg) were studied in vivo and in vitro. In previtellogenic trout, cortisol implantation strongly decreased rtER mRNA levels, and to a lower extent those of Vg mRNAs. In aggregated cultured hepatocytes, both basal and E2-stimulated rtER messenger levels were consistently inhibited by dexamethasone (Dex) treatment, demonstrating the direct effects of glucocorticoid inhibition on liver cells. Moreover, as the half-life of the rtER mRNAs was not affected by Dex, this inhibition is likely mediated by a transcriptional repression of the rtER gene. |
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