Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis
Aiello, A.; D'Esposito, M.; Fattorusso, E.; Menna, M.; Müller, W.E.G.; Perovic-Ottstadt, S.; Tsuruta, H.; Gulder, T.A.M.; Bringmann, G. (2005). Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis. Tetrahedron 61(30): 7266-7270. https://dx.doi.org/10.1016/j.tet.2005.05.025
In: Tetrahedron. Pergamon Press: New York; Oxford; Paris; Frankfurt. ISSN 0040-4020; e-ISSN 1464-5416, more
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| Keywords |
Axinella damicornis (Esper, 1794) [WoRMS]
Marine/Coastal |
| Authors | | Top | Dataset |
- Aiello, A.
- D'Esposito, M.
- Fattorusso, E.
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- Menna, M.
- Müller, W.E.G.
- Perovic-Ottstadt, S.
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- Tsuruta, H.
- Gulder, T.A.M.
- Bringmann, G.
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| Abstract |
The isolation and characterization of the known pyrrole alkaloid agelongine (6) and of the new natural product daminin (7), the bromine-free analogue of 6, from a specimen of the marine sponge Axinella damicornis is described. Compound 7 showed significant neuroprotective properties. Moreover, for the supply of sufficient material for future medicinal investigations, a short total synthesis of 7 was developed. |
| Dataset |
- Linares, Cristina; Figuerola, Laura; Gómez-Gras, Daniel; Pagès-Escolà, Marta; Olvera, Àngela, Aubach, Àlex; Amate, Roger; Figuerola, Blanca; Kersting, Diego; Ledoux, Jean-Baptiste; López-Sanz, Àngel; López-Sendino, Paula; Medrano, Alba; Garrabou, Joaquim; (2020); CorMedNet- Distribution and demographic data of habitat-forming invertebrate species from Mediterranean coralligenous assemblages between 1882 and 2019, more
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