Voltage dependence of sodium channel inactivation in the squid giant axon

Greeff, N.G.; Forster, I.C.

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Voltage dependence of sodium channel inactivation in the squid giant axon

Greeff, N.G.; Forster, I.C. (1995). Voltage dependence of sodium channel inactivation in the squid giant axon, in: Abbott, N.J. et al. (Ed.) Cephalopod neurobiology: neuroscience studies in squid, octopus and cuttlefish. pp. 107-118

In: Abbott, N.J.; Williamson, R.; Maddock, L. (Ed.) (1995). Cephalopod neurobiology: Neuroscience studies in squid, octopus and cuttlefish. Oxford University Press: London. ISBN 0-19-854790-0. 542 pp. https://dx.doi.org/10.1093/acprof:oso/9780198547907.001.0001, more

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Greeff, N.G. Forster, I.C.

Abstract

The current views about voltage dependence of sodium channel inactivation are rather divergent. In this study we show that high resolution recording of gating current from the squid giant axon detects a slow component during the inactivation phase of sodium ionic current. From the combined data of ionic and gating current we obtained with a new approach (isochronic analysis) an estimate of about 1.2 electron charges for the voltage dependence of microscopic sodium inactivation, i.e. the quantal gating charge of the open-to-inactivated transition. This method also reveals that conventional rate analysis of the inactivation of sodium ionic currents will estimate the voltage dependence correctly between -10 and +40 mV but not at lower voltages. Taking this constraint into account would resolve most of the previous controversies.

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