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Report of in vitro antileishmanial properties of Iberian macroalgae
Lago, J.H.G.; Macridachis, J.; Oliveira, M.; Brito, L.; Vizetto-Duarte, C.; Florindo, C.; Hendrickx, S.; Maes, L.; Morais, T.; Uemi, M.; Neto, L.; Dionísio, L.; Cortes, S.; Barreira, L.; Custodio, L.; Alberício, F.; Varela, J. (2019). Report of in vitro antileishmanial properties of Iberian macroalgae. Nat. Prod. Res. 33(12): 1778-1782. https://dx.doi.org/10.1080/14786419.2018.1434637
In: Natural Product Research. Taylor & Francis: Abingdon. ISSN 1478-6419; e-ISSN 1478-6427, more
Peer reviewed article  
Available in  Authors 
Keywords
    Cystoseira C.Agardh, 1820 [WoRMS]; Leishmania infantum
    Marine/Coastal
Author keywords
    Antiparasitic; Leishmania infantum; leishmaniasis; macroalgae;Cystoseira; secondary metabolites
Authors  Top 
  • Lago, J.H.G.
  • Macridachis, J.
  • Oliveira, M.
  • Brito, L.
  • Vizetto-Duarte, C.
  • Florindo, C.
  • Hendrickx, S., more
  • Maes, L., more
  • Morais, T.
  • Uemi, M.
  • Neto, L.
  • Dionísio, L.
  • Cortes, S.
  • Barreira, L.
  • Custodio, L.
  • Alberício, F.
  • Varela, J.
Abstract
    Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.
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