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New halogenated C15 acetogenins from Okinawan sea hare Aplysia dactylomela
Matsuyama, K.; Inoue, T.; Muroga, T.; Arima, N.; Doe, M.; Tani, F.; Ookawa, Y.; Okamoto, Y.; Onitsuka, S.; Okamura, H.; Iwagawa, T.; Hamada, T. (2022). New halogenated C15 acetogenins from Okinawan sea hare Aplysia dactylomela. Tetrahedron 120: 132889. https://dx.doi.org/10.1016/j.tet.2022.132889
In: Tetrahedron. Pergamon Press: New York; Oxford; Paris; Frankfurt. ISSN 0040-4020; e-ISSN 1464-5416, more
Peer reviewed article  
Available in  Authors 
Keywords
    Aplysia dactylomela Rang, 1828 [WoRMS]
    Marine/Coastal
Author keywords
    Sea hare; Aplysia dactylomela; Halogenated C15 acetogenins; Relative stereochemistry; Adult T-cell leukemia; Cytotoxicity
Authors  Top 
  • Matsuyama, K.
  • Inoue, T.
  • Muroga, T.
  • Arima, N.
  • Doe, M.
  • Tani, F.
  • Ookawa, Y.
  • Okamoto, Y.
  • Onitsuka, S.
  • Okamura, H.
  • Iwagawa, T.
  • Hamada, T.
Abstract
    Two new C15 acetogenins 1 and 2, along with four known sesquiterpenes isolaurenisol (3), laurokamurene D (4), itomanol (5), and acetylelatol (6), were isolated from sea hare Aplysia dactylomela. The structures, including the relative stereochemistries, of 1 and 2 were determined based on spectroscopic evidence. Finally, the in vitro cytotoxicities of the six compounds against S1T cells, an adult T-cell leukemia cell line, were evaluated.
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