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Prof. Dr Tytgat, Jan
ResearcherID

KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen; Laboratorium voor Toxicologie en Farmacologie, more

Function: Head of unit
Direct contact at institute:
Tel.: +32-(0)16-32 34 03
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A1 Publications (87) [show]
Depuydt, A.-S.; Patel, P.A.; Toplak, Ž.; Bhat, C.; Vorácová, M.; Eteläinen, I.; Vitulano, F.; Bruun, T.; Lempinen, A.; Hribernik, N.; Mäki-Lohiluoma, E.; Hendrickx, L.; Pinheiro-Junior, E.L.; Tomašic, T.; Mašic, L.P.; Yli-Kauhaluoma, J.; Kiuru, P.; Tytgat, J.; Peigneur, S. (2023). Structure-function studies of sponge-derived compounds on the cardiac CaV3.1 channel. International Journal of Molecular Sciences 24(4): 3429. https://dx.doi.org/10.3390/ijms24043429, more An, D.; Pinheiro-Junior, E.L.; Béress, L.; Gladkikh, I.; Leychenko, E.; Undheim, E.A.B.; Peigneur, S.; Tytgat, J. (2022). AsKC11, a Kunitz peptide from Anemonia sulcata, is a novel activator of G protein-coupled inward-rectifier potassium channels. Mar. Drugs 20(2): 140. https://dx.doi.org/10.3390/md20020140, more Kalina, R.S.; Kasheverov, I.E.; Koshelev, S.G.; Sintsova, O.V.; Peigneur, S.; Pinheiro-Junior, E.L.; Popov, R.S.; Chausova, V.; Monastyrnaya, M.M.; Dmitrenok, P.S.; Isaeva, M.P.; Tytgat, J.; Kozlov, S.A.; Kozlovskaya, E.P.; Leychenko, E.V.; Gladkikh, I.N. (2022). Nicotinic acetylcholine receptors are novel targets of APETx-like toxins from the sea anemone Heteractis magnifica. Toxins 14(10): 697. https://dx.doi.org/10.3390/toxins14100697, more Kvetkina, A.; Pislyagin, E.; Menchinskaya, E.; Yurchenko, E.; Kalina, R.; Kozlovskiy, S.; Kaluzhskiy, L.; Kim, N.; Peigneur, S.; Tytgat, J.; Ivanov, A.; Ayvazyan, N.; Leychenko, E.; Aminin, D. (2022). Kunitz-type peptides from sea anemones protect neuronal cells against Parkinson's disease inductors via inhibition of ROS production and ATP-induced P2X7 receptor activation. International Journal of Molecular Sciences 23(9): 5115. https://dx.doi.org/10.3390/ijms23095115, more Laborde, Q.; Peigneur, S.; Andersson, H.; Tytgat, J.; Jacobsson, E.; Goransson, U. (2022). The toxicity of α-nemertide 1 peptide alanine-mutants from the marine nemertean worm Lineus longissimus. Journal of Peptide Science 28: P004, more Pinheiro-Junior, E.L.; Kalina, R.; Gladkikh, I.; Leychenko, E.; Tytgat, J.; Peigneur, S. (2022). A tale of toxin promiscuity: the versatile pharmacological effects of Hcr 1b-2 sea anemone peptide on voltage-gated ion channels. Mar. Drugs 20(2): 147. https://dx.doi.org/10.3390/md20020147, more Schmidt, C.A.; Cooke, I.; Wilson, D.T.; Miller, D.J.; Peigneur, S.; Tytgat, J.; Field, M.; Takjoo, R.; Smout, M.J.; Loukas, A.; Daly, N.L. (2022). Newly discovered peptides from the coral Heliofungia actiniformis show structural and functional diversity. J. Nat. Prod. 85(7): 1789-1798. https://dx.doi.org/10.1021/acs.jnatprod.2c00325, more Wiere, S.; Sugai, C.; Espiritu, M.J.; Aurelio, V.P.; Reyes, C.D.; Yuzon, N.; Whittal, R.M.; Tytgat, J.; Peigneur, S.; Bingham, J.-P. (2022). Research into the bioengineering of a novel α-conotoxin from the milked venom of Conus obscurus. International Journal of Molecular Sciences 23(20): 12096. https://dx.doi.org/10.3390/ijms232012096, more Jacobsson, E.; Peigneur, S.; Andersson, H.S.; Laborde, Q.; Strand, M.; Tytgat, J.; Goransson, U. (2021). Functional characterization of the nemertide α family of peptide toxins. J. Nat. Prod. 84(8): 2121-2128. https://dx.doi.org/10.1021/acs.jnatprod.1c00104, more Mitchell, M.L.; Hossain, M.A.; Lin, F.; Pinheiro-Junior, E.L.; Peigneur, S.; Wai, D.C.C.; Delaine, C.; Blyth, A.J.; Forbes, B.E.; Tytgat, J.; Wade, J.D.; Norton, R.S. (2021). Identification, synthesis, conformation and activity of an insulin-like peptide from a sea anemone. Biomolecules 11(12): 1785. https://dx.doi.org/10.3390/biom11121785, more Sintsova, O.; Gladkikh, I.; Monastyrnaya, M.; Tabakmakher, V.; Yurchenko, E.; Menchinskaya, E.; Pislyagin, E.; Andreev, Y.; Kozlov, S.; Peigneur, S.; Tytgat, J.; Aminin, D.; Kozlovskaya, E.; Leychenko, E. (2021). Sea anemone Kunitz-type peptides demonstrate neuroprotective activity in the 6-hydroxydopamine induced neurotoxicity model. Biomedicines 9(3): 283. https://hdl.handle.net/10.3390/biomedicines9030283, more Gladkikh, I.; Peigneur, S.; Sintsova, O.; Pinheiro-Junior, E.L.; Klimovich, A.; Menshov, A.; Kalinovsky, A.; Isaeva, M.; Monastyrnaya, M.; Kozlovskaya, E.; Tytgat, J.; Leychenko, E. (2020). Kunitz-type peptides from the sea anemone Heteractis crispa demonstrate potassium channel blocking and anti-inflammatory activities. Biomedicines 8(11): 473. https://hdl.handle.net/10.3390/biomedicines8110473, more Kalina, R.S.; Peigneur, S.; Zelepuga, E.A.; Dmitrenok, P.S.; Kvetkina, A.N.; Kim, N.Y.; Leychenko, E.V.; Tytgat, J.; Kozlovskaya, E.P.; Monastyrnaya, M.M.; Gladkikh, I.N. (2020). New insights into the type II toxins from the sea anemone Heteractis crispa. Toxins 12(1): 44. https://hdl.handle.net/10.3390/toxins12010044, more Kalina, R.S.; Peigneur, S.; Gladkikh, I.N.; Dmitrenok, P.S.; Kim, N.Y.; Leychenko, E.V.; Monastyrnaya, M.M.; Tytgat, J.; Kozlovskaya, E.P. (2020). New sea anemone toxin RTX-VI selectively modulates voltage-gated sodium channels. Doklady Biochemistry and Biophysics 495(1): 292-295. https://hdl.handle.net/10.1134/S1607672920060071, more Kvetkina, A.; Leychenko, E.; Chausova, V.; Zelepuga, E.; Chernysheva, N.; Guzev, K.; Pislyagin, E.; Yurchenko, E.; Menchinskaya, E.; Aminin, D.; Kaluzhskiy, L.; Ivanov, A.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E.; Isaeva, M. (2020). A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine. NPG Scientific Reports 10(1): 4205. https://hdl.handle.net/10.1038/s41598-020-61034-x, more Schmidt, C.A.; Wilson, D.T.; Cooke, I.; Potriquet, J.; Tungatt, K.; Muruganandah, V.; Boote, C.; Kuek, F.; Miles, J.J.; Kupz, A.; Ryan, S.; Loukas, A.; Bansal, P.S.; Takjoo, R.; Miller, D.J.; Peigneur, S.; Tytgat, J.; Daly, N.L. (2020). Identification and characterization of a peptide from the stony coral Heliofungia actiniformis. J. Nat. Prod. 83(11): 3454-3463. https://hdl.handle.net/10.1021/acs.jnatprod.0c00981, more Andersson, H.S.; Jacobsson, E.; Strand, M.; Peigneur, S.; Lebbe, E.K.M.; Rosengren, K.J.; Goransson, U.; Tytgat, J. (2019). α-nemertides, a novel family of marine peptide neurotoxins from ribbon worms. Toxicon 158(S1): S38-S39. https://hdl.handle.net/10.1016/j.toxicon.2018.10.136, more Elnahriry, K.A.; Wai, D.C.C.; Krishnarjuna, B.; Badawy, N.N.; Chittoor, B.; MacRaild, C.A.; Williams-Noonan, B.J.; Surm, J.M.; Chalmers, D.K.; Zhang, A.H.; Peigneur, S.; Mobli, M.; Tytgat, J.; Prentis, P.; Norton, R.S. (2019). Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon 168: 104-112. https://dx.doi.org/10.1016/j.toxicon.2019.07.002, more Gladkikh, I.; Kalina, R.; Sinsova, O.; Kvetkina, A.; Peigneur, S.; Koshelev, S.; Kim, N.; Monastyrnaya, M.; Kozlov, S.; Tytgat, J.; Kozlovskaya, E. (2019). New Kv, NAv, and ASIC channel toxins from the sea anemone Heteractis crispa. Toxicon 158(S1): S48-S48. https://hdl.handle.net/10.1016/j.toxicon.2018.10.168, more Peigneur, S.; Cheneval, O.; Maiti, M.; Leipold, E.; Heinemann, S.H.; Lescrinier, E.; Herdewijn, P.; de Lima, M.E.; Craik, D.J.; Schroeder, C.I.; Tytgat, J. (2019). Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB J. 33(3): 3693-3703. https://dx.doi.org/10.1096/fj.201801909R, more Peigneur, S.; Devi, P.; Seldeslachts, A.; Ravichandran, S.; Quinton, L.; Tytgat, J. (2019). Structure-function elucidation of a new α-conotoxin, MiIIA, from Conus milneedwardsi. Mar. Drugs 17(9): 535. https://dx.doi.org/10.3390/md17090535, more Sachkova, M.Y.; Singer, S.A.; Macrander, J.; Reitzel, A.M.; Peigneur, S.; Tytgat, J.; Moran, Y. (2019). The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella. Mol. Biol. Evol. 36(9): 2001-2012. https://dx.doi.org/10.1093/molbev/msz132, more Sintsova, O.; Kalinovskii, A.; Gladkikh, I.; Zelepuga, E.; Monastyrnaya, M.; Kim, N.; Shevchenko, L.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E.; Leychenko, E. (2019). Magnificamide, a β-defensin-like peptide from the mucus of the sea anemone Heteractis magnifica, is a strong inhibitor of mammalian α-amylases. Mar. Drugs 17(10): 542. https://dx.doi.org/10.3390/md17100542, more Zelepuga, E.; Gladkikh, I.; Peigneur, S.; Tytgat, J.; Monastyrnaya, M.; Kozlovskaya, E. (2019). The Kunitz-type HCRG peptides from the sea anemone Heteractis crispa possess Kv channel toxicity. Toxicon 159(S1): S26-S27. https://hdl.handle.net/10.1016/j.toxicon.2018.11.408, more Jacobsson, E.; Andersson, H.S.; Strand, M.; Peigneur, S.; Eriksson, C.; Loden, H.; Shariatgorji, M.; Andren, P.E.; Lebbe, E.K.M.; Rosengren, K.J.; Tytgat, J.; Goransson, U. (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. NPG Scientific Reports 8: 10. https://dx.doi.org/10.1038/s41598-018-22305-w, more Krishnarjuna, B.; Villegas-Moreno, J.; Mitchell, M.L.; Csoti, A.; Peigneur, S.; Amero, C.; Pennington, M.W.; Tytgat, J.; Panyi, G.; Norton, R.S. (2018). Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold. Toxicon 150: 50-59. https://dx.doi.org/10.1016/j.toxicon.2018.05.006, more Krishnarjuna, B.; MacRaild, C.A.; Sunanda, P.; Morales, R.A.V.; Peigneur, S.; Macrander, J.; Yu, H.H.; Daly, M.; Raghothama, S.; Chauhan, S.; Tytgat, J.; Pennington, M.W.; Norton, R.S. (2018). Corrigendum to“Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK”[Peptides 99 (2018) 169–178]. Peptides (New York, NY : 1980) 101: 234-234. https://dx.doi.org/10.1016/j.peptides.2018.01.008, more Krishnarjuna, B.; MacRaild, C.A.; Sunanda, P.; Morales, R.A.V.; Peigneur, S.; Macrander, J.; Yu, H.H.; Daly, M.; Raghothama, S.; Dhawan, V.; Chauhan, S.; Tytgat, J.; Pennington, M.W.; Norton, R.S. (2018). Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK. Peptides (New York, NY : 1980) 99: 169-178. https://dx.doi.org/10.1016/j.peptides.2017.10.001, more Madio, B.; Peigneur, S.; Chin, Y.K.Y.; Hamilton, B.; Henriques, S.T.; Smith, J.J.; Cristofori-Armstrong, B.; Dekan, Z.; Boughton, B.A.; Alewood, P.F.; Tytgat, J.; King, G.F.; Undheim, E.A.B. (2018). PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular and molecular life sciences 75(24): 4511-4524. https://dx.doi.org/10.1007/s00018-018-2897-6, more Orts, D.J.B.; Peigneur, S.; Silva-Goncalves, L.C.; Arcisio-Miranda, M.; Bicudo, J.E.P.W.; Tytgat, J. (2018). AbeTx1 is a novel sea anemone toxin with a dual mechanism of action on Shaker-type K+ channels activation. Mar. Drugs 16(10): 360. https://dx.doi.org/10.3390/md16100360, more Peigneur, S.; de Lima, M.E.; Tytgat, J. (2018). Phoneutria nigriventer venom: a pharmacological treasure. Toxicon 151: 96-110. https://dx.doi.org/10.1016/j.toxicon.2018.07.008, more Rodríguez, A.A.; Garateix, A.; Salceda, E.; Peigneur, S.; Zaharenko, A.J.; Pons, T.; Santos, Y.; Arreguin, R.; Ständker, L.; Forssmann, W.-G.; Tytgat, J.; Vega, R.; Soto, E. (2018). PhcrTx2, a new crab-paralyzing peptide toxin from the sea anemone Phymanthus crucifer. Toxins 10(2): 72. https://dx.doi.org/10.3390/toxins10020072, more Sunanda, P.; Krishnarjuna, B.; Peigneur, S.; Mitchell, M.L.; Estrada, R.; Villegas-Moreno, J.; Pennington, M.W.; Tytgat, J.; Norton, R.S. (2018). Identification, chemical synthesis, structure, and function of a new K_V1 channel blocking peptide from Oulactis sp. Peptide Science 110(4): e24073. https://dx.doi.org/10.1002/pep2.24073, more Montero-Alejo, V.; Corzo, G.; Porro-Suardiaz, J.; Pardo-Ruiz, Z.; Perera, E.; Rodriguez-Viera, L.; Sanchez-Diaz, G.; Alvarez, C.; Peigneur, S.; Tytgat, J.; Perdomo-Morales, R. (2017). Panusin represents a new family of β-defensin-like peptides in invertebrates. Dev. Comp. Immunol. 67: 310-321. https://dx.doi.org/10.1016/j.dci.2016.09.002, more Moreels, L.; Bhat, C.; Vorácová, M.; Peigneur, S.; Mäki-Lohiluoma, E.; Zahed, F.; Pardo, L.A.; Yli-Kauhaluoma, J.; Kiuru, P.; Tytgat, J. (2017). Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancerrelevant potassium channel K_V10.1. PLoS One 12(12): e0188811. https://dx.doi.org/10.1371/journal.pone.0188811, more Moreels, L.; Peigneur, S.; Galan, D.T.; De Pauw, E.; Béress, L.; Waelkens, E.; Pardo, L.A.; Quinton, L.; Tytgat, J. (2017). APETx4, a novel sea anemone toxin and a modulator of the cancer-relevant potassium channel K_V10.1. Mar. Drugs 15(9): 287. https://dx.doi.org/10.3390/md15090287, more Zidar, N.; Zula, A.; Tomašic, T.; Rogers, M.; Kirby, R.W.; Tytgat, J.; Peigneur, S.; Kikelj, D.; Ilas, J.; Masic, L.P. (2017). Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur. J. Med. Chem. 139: 232-241. https://dx.doi.org/10.1016/j.ejmech.2017.08.015, more García-Fernández, R.; Peigneur, S.; Pons, T.; Alvarez, C.; González, L.; Chávez, M.A.; Tytgat, J. (2016). The Kunitz-type protein ShPI-1 inhibits serine proteases and voltage-gated potassium channels. Toxins 8(4): 110. dx.doi.org/10.3390/toxins8040110, more Kopljar, I.; Grottesi, A.; de Block, T.; Rainier, J.D.; Tytgat, J.; Labro, A.J.; Snyders, D.J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology 107: 160-167. https://dx.doi.org/10.1016/j.neuropharm.2016.03.010, more Lebbe, E.K.M.; Ghequire, M.G.K.; Peigneur, S.; Mille, B.G.; Devi, P.; Ravichandran, S.; Waelkens, E.; D'Souza, L.; De Mot, R.; Tytgat, J. (2016). Novel conopeptides of largely unexplored Indo Pacific Conus sp. Mar. Drugs 14(11): 18 pp. https://dx.doi.org/10.3390/md14110199, more Lebbe, E.K.M.; Tytgat, J. (2016). In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds. Journal of Venomous Animals and Toxins Including Tropical Diseases 22: 15 pp. https://dx.doi.org/10.1186/s40409-016-0083-6, more Martínez-Morales, E.; Kopljar, I.; Rainier, J.D.; Tytgat, J.; Snyders, D.J.; Labro, A.J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon 120: 57-60. https://dx.doi.org/10.1016/j.toxicon.2016.07.017, more Monastyrnaya, M.; Peigneur, S.; Zelepuga, E.; Sintsova, O.; Gladkikh, I.; Leychenko, E.; Isaeva, M.; Tytgat, J.; Kozlovskaya, E. (2016). Kunitz-type peptide HCRG21 from the sea anemone Heteractis crispa is a full antagonist of the TRPV1 receptor. Mar. Drugs 14(12): 229. https://dx.doi.org/10.3390/md14120229, more Jukic, M.; Frlan, R.; Chan, F.; Kirby, R.; Madge, D.; Tytgat, J.; Peigneur, S.; Anderluh, M.; Kikelj, D. (2015). Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Na_v) 1.3 channel modulators. Med. Chem. Res. 24(6): 2366-2380. dx.doi.org/10.1007/s00044-014-1300-x, more Sintsova, O.; Chausova, V.; Gladkikh, I.; Isaeva, M.; Tabakmaher, V.; Monastyrnaya, M.; Leychenko, E.; Pislyagin, E.; Menchinskaya, E.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). New antihistamine Kunitz-type polypeptides of the sea anemones, Heteractis crispa and Stichodactyla mertensii. The FEBS Journal 282(Suppl. 1): 140-141, more Zelepuga, E.; Gladkikh, I.; Monastyrnaya, M.; Sintsova, O.; Tabakmaher, V.; Peigneur, S.; Tytgat, J.; Kozlovskaya, E. (2015). The sea anemone Heteractis crispa - a source of potential pharmacological agents. The FEBS Journal 282(Suppl. 1): 322-323, more Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Mille, B.G.; Devi, P; Ravichandran, S; Lescrinier, E.; Waelkens, E.; D'Souza, L; Herdewijn, P.; Tytgat, J. (2014). Discovery of a new subclass of alpha-conotoxins in the venom of Conus australis. Toxicon 91: 145-154. https://dx.doi.org/10.1016/j.toxicon.2014.08.074, more Lebbe, E.K.M.; Peigneur, S.; Wijesekara, I.; Tytgat, J. (2014). Conotoxins targeting nicotinic acetylcholine receptors: an overview. Mar. Drugs 12(5): 2970-3004. dx.doi.org/10.3390/md12052970, more Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P.; Ravichandran, S.; Lescrinier, E.; Ulens, C.; Waelkens, E.; D'Souza, L.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. J. Biol. Chem. 289(14): 9573-9583. https://dx.doi.org/10.1074/jbc.M114.556175, more Lebbe, E.K.M.; Peigneur, S.; Maiti, M.; Devi, P; Ravichandran, S; D'Souza, L; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2014). Structure-function elucidation of a new alpha-conotoxin, Lo1a, from Conus longurionis. Toxicon 91: 170-171. dx.doi.org/10.1016/j.toxicon.2014.08.023, more Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J. (2014). Action of Clathrodin and analogues on voltage-gated sodium channels. Mar. Drugs 12(4): 2132-2143. dx.doi.org/10.3390/md12042132, more Peigneur, S.; Tytgat, J. (2014). When cone snails and spiders meet: design of selective and potent sodium channel inhibitors. Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.022, more Rodriguez, A; Salceda, E; Garateix, G; Zaharenko, J; Peigneur, S.; Lopez, O; Pons, T; Richardson, M; Diaz, M; Hernandez, Y; Standker, L; Tytgat, J.; Soto, E (2014). A novel sea anemone peptide that inhibits acid-sensing ion channels. Peptides (New York, NY : 1980) 53: 3-12. dx.doi.org/10.1016/j.peptides.2013.06.003, more Tytgat, J. (2014). Sea anemone toxins: from lab bench discovery to commercial drugs? Toxicon 91: 170-170. dx.doi.org/10.1016/j.toxicon.2014.08.021, more Wijesekara, I.; Peigneur, S.; Devi, P; Ravichandran, S; Lebbe, E.; Mille, B.; D'Souza, L; Tytgat, J. (2014). Isolation and characterization of novel conopeptides from Conus amadis that target voltage-gated sodium channels. Toxicon 91: 184-184. dx.doi.org/10.1016/j.toxicon.2014.08.056, more Zhu, S.; Peigneur, S.; Gao, B.; Umetsu, Y.; Ohki, S.; Tytgat, J. (2014). Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function. Mol. Biol. Evol. 31(3): 546-559. https://dx.doi.org/10.1093/molbev/msu038, more Zidar, N.; Jakopin, Z.; Madge, D.; Chan, F.; Tytgat, J.; Peigneur, S.; Dolenc, M.; Tomasic, T.; Ilas, J.; Masic, L.; Kikelj, D. (2014). Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators. Eur. J. Med. Chem. 74: 23-30. dx.doi.org/10.1016/j.ejmech.2013.12.034, more Bergeron, Z.L.; Chun, J.B.; Baker, M.R.; Sandall, D.W.; Peigneur, S.; Yu, P.Y.C.; Thapa, P.; Milisen, J.W.; Tytgat, J.; Livett, B.G.; Bingham, J.P. (2013). A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile-The pharmacological importance of post-translational modifications. Peptides (New York, NY : 1980) 49: 145-158. dx.doi.org/10.1016/j.peptides.2013.09.004, more Cassoli, J.; Verano-Braga, T.; Oliveira, J.; Montandon, G.; Cologna, C.T.; Peigneur, S.; Pimenta, A.; Kjeldsen, F.; Roepstorff, P.; Tytgat, J.; de Lima, M. (2013). The proteomic profile of Stichodactyla duerdeni secretion reveals the presence of a novel O-linked glycopeptide. J. Proteomics 87: 89-102. https://dx.doi.org/10.1016/j.jprot.2013.05.022, more Kendel, Y.; Melaun, C.; Kurz, A.; Nicke, A.; Peigneur, S.; Tytgat, J.; Wunder, C.; Mebs, D.; Kauferstein, S. (2013). Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors. Toxins 5(5): 1043-1050. dx.doi.org/10.3390/toxins5051043, more Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.; Tytgat, J.; Snyders, D.J. (2013). The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J. Gen. Physiol. 141(3): 359-369. https://dx.doi.org/10.1085/jgp.201210890, more Orts, D.J.B.; Peigneur, S.; Madio, B.; Cassoli, J.S.; Montandon, G.G.; Pimenta, A.M.C.; Bicudo, J.E.P.W.; Freitas, J.C.; Zaharenko, A.J.; Tytgat, J. (2013). Biochemical and electrophysiological characterization of two sea anemone Type 1 Potassium toxins from a geographically distant population of Bunodosoma caissarum. Mar. Drugs 11(3): 655-679. dx.doi.org/10.3390/md11030655, more Orts, D.J.B.; Moran, Y.; Cologna, C.T.; Peigneur, S.; Madio, B.; Praher, D.; Quinton, L.; De Pauw, E.; Bicudo, J.E.P.W.; Tytgat, J.; de Freitas, J.C. (2013). BcsTx3 is a founder of a novel sea anemone toxin family of potassium channel blocker. The FEBS Journal 280(19): 4839-4852. dx.doi.org/10.1111/febs.12456, more Peigneur, S.; Van Der Haegen, A.; Möller, C.; Waelkens, E.; Diego-García, E.; Marí, F.; Naudé, R.; Tytgat, J. (2013). Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis. Peptides (New York, NY : 1980) 41: 8-16. https://dx.doi.org/10.1016/j.peptides.2012.07.002, more Stas, J.; Kopljar, I.; Labro, A.; Peigneur, S.; Zaharenko, A.J.; Tytgat, J.; Snyders, D.J. (2013). A gating modulator peptide toxin for Shaker-type K_v1 channels derived from the sea anemone Bunodosoma cangicum. Biophys. J. 104(2): 125A-125A, more Tomašic, T.; Hartzoulakis, B.; Zidar, N.; Chan, F.; Kirby, R.W.; Madge, D.J.; Peigneur, S.; Tytgat, J.; Kikelj, D. (2013). Ligand- and structure-based virtual screening for clathrodin-derived human voltage-gated sodium channel modulators. Journal of Chemical Information and Modeling 53(12): 3223-3232. https://dx.doi.org/10.1021/ci400505e, more Gladkikh, I.; Monastyrnaya, M.; Leychenko, E.; Zelepuga, E.; Chausova, V.; Isaeva, M.; Anastyuk, S.; Andreev, Y.; Peigneur, S.; Tytgat, J.; Kozlovkaya, E. (2012). Atypical reactive center Kunitz-type inhibitor from the sea anemone Heteractis crispa. Mar. Drugs 10(7): 1545-1565. http://dx.doi.org/10.3390/md10071545, more Kopljar, I.; Labro, A.J.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2012). Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin Gambierol. Toxicon 60(2): 150-151. dx.doi.org/10.1016/j.toxicon.2012.04.111, more Peigneur, S.; Lescrinier, E.; Moller, C.; Mari, F.; Beress, L.; Tytgat, J. (2012). A natural point mutation reveals target promiscuity of toxins isolated from the sea anemone Anthopleura elegantissima. Biophys. J. 102(3, Supplement 1): 658A-658A, more Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2012). A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J. 26(12): 5141-5151. http://dx.doi.org/10.1096/fj.12-218479, more Stevens, M.; Peigneur, S.; Dyubankova, N.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Design of bioactive peptides from naturally occurring µ-conotoxin structures. J. Biol. Chem. 287(37): 31382-31392. dx.doi.org/10.1074/jbc.M112.375733, more Van Der Haegen, A.; Peigneur, S.; Dyubankova, N.; Moller, C.; Mari, F.; Diego-García, E.; Naude, R.; Lescrinier, E.; Herdewijn, P.; Tytgat, J. (2012). Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity. Peptides (New York, NY : 1980) 34(1): 106-113. dx.doi.org/10.1016/j.peptides.2011.10.026, more Cuypers, E.; Peigneur, S.; Debaveye, S.; Shiomi, K.; Tytgat, J. (2011). TRPV1 channel as new target for marine toxins: Example of gigantoxin I, a sea anemone toxin acting via modulation of the PLA₂ pathway. Acta Chim. Slov. 58(4): 735-741, more Peigneur, S.; Billen, B.; Derua, R.; Waelkens, E.; Debaveye, S.; Béress, L.; Tytgat, J. (2011). A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. Biochem. Pharmacol. 82(1): 81-90. https://dx.doi.org/10.1016/j.bcp.2011.03.023, more Van Der Haegen, A.; Peigneur, S.; Tytgat, J. (2011). Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. The FEBS Journal 278(18): 3408-3418. dx.doi.org/10.1111/j.1742-4658.2011.08264.x, more Billen, B.; Debaveye, S.; Béress, L.; Garateixand, A.; Tytgat, J. (2010). Phyla- and subtype-selectivity of CgNa, a Na⁺ channel toxin from the venom of the Giant Caribbean Sea Anemone Condylactis gigantea. Front. Pharmacol. 1: 133. http://dx.doi.org/10.3389/fphar.2010.00133, more Kopljar, I.; Labro, A.J.; Cuypers, E.; Johnson, H.W.B.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2009). A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc. Natl. Acad. Sci. U.S.A. 106(24): 9896-9901. http://dx.doi.org/10.1073/pnas.0812471106, more Cuypers, E.; Abdel-Mottaleb, Y.; Kopljar, I.; Rainier, J.; Raes, A.L.; Snyders, D.J.; Tytgat, J. (2008). Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon 51(6): 974-983. https://dx.doi.org/10.1016/j.toxicon.2008.01.004, more Bosmans, F.; Tytgat, J. (2007). Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na⁺ channels. Toxicon 49(4): 550-560. dx.doi.org/10.1016/j.toxicon.2006.11.029, more Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. (2007). TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem. Biophys. Res. Commun. 361(1): 214-217. dx.doi.org/10.1016/j.bbrc.2007.07.009, more Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2007). Corrigendum to "Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels" [FEBS Lett. 580 (2006) 5728-5732]. FEBS Lett. 581(8): 1699. dx.doi.org/10.1016/j.febslet.2007.03.036, more Cuypers, E.; Yanagihara, A.; Karlsson, E.; Tytgat, J. (2006). Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett. 580(24): 5728-5732. dx.doi.org/10.1016/j.febslet.2006.09.030, more Kauferstein, S.; Huys, I.; Kuch, U.; Melaun, C.; Tytgat, J.; Mebs, D. (2004). Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon 44(5): 539-548, more Fan, C.X.; Chen, X.K.; Zhang, C.; Wang, L.X.; Duan, K.L.; He, L.L.; Cao, Y.; Liu, S.Y.; Zhong, M.N.; Ulens, C.; Tytgat, J.; Chen, J.S.; Chi, C.W.; Zhou, Z. (2003). A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J. Biol. Chem. 278(15): 12624-12633. https://dx.doi.org/10.1074/jbc.M210200200, more Kauferstein, S.; Huys, I.; Lamthanh, H.; Stöcklin, R.; Sotto, F.; Menez, A.; Tytgat, J.; Mebs, D. (2003). A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels. Toxicon 42(1): 43-52. https://dx.doi.org/10.1016/S0041-0101(03)00099-0, more Bosmans, F.; Aneiros, A.; Tytgat, J. (2002). The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett. 532(1-2): 131-134. dx.doi.org/10.1016/S0014-5793(02)03653-0, more Goudet, C.; Ferrero, T.; Galàn, L.; Artiles, A.; Batista, C.F.V.; Possani, L.D.; Alvarez, J.; Aneiros, A.; Tytgat, J. (2001). Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels. Br. J. Pharmacol. 134(6): 1195-1206. dx.doi.org/10.1038/sj.bjp.0704361, more
Books (2) [show]
Tytgat, J. (2017). α-Nemertides, a novel family of marine peptide neurotoxins from ribbon worms. KULeuven: Leuven. , more Tytgat, J. (2007). Toxines van kwallen en zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Katholieke Universiteit Leuven. Faculteit Farmaceutische Wetenschappen. Laboratorium Toxicologie: Leuven. 23 pp., more
Book chapters (2) [show]
Kopljar, I.; Peigneur, S.; Snyders, D.J.; Tytgat, J. (2014). The mechanism of action of microalgal toxins interacting with Na_v and Kv channels, in: Rossini, G.P. (Ed.) Toxins and biologically active compounds from microalgae: Volume 2. Biological effects and risk management. pp. 3-34, more Marí, F.; Tytgat, J. (2010). 2.15 – Natural Peptide Toxins, in: Mander, L.N. et al. Comprehensive natural products II. Chemistry and biology. pp. 511-538. http://dx.doi.org/10.1016/B978-008045382-8.00638-9, more
Abstracts (3) [show]
De Raedemaecker, F.; Sandra, M.; Devriese, L; Goeminne, G.; Bicalho, K.; Montoye, T.; Tytgat, J.; Bernaerts, H.; Coenye, T.; Van Vlierberghe, W.; Loosvelt , L. (2021). Prospection for bioactive compounds in the North Sea: Creating a knowledge base for blue biotech innovation in Flanders, in: Mees, J. et al. Book of abstracts – VLIZ Marine Science Day, Online event 3 March 2021. VLIZ Special Publication, 87: pp. 45, more Peigneur, S.; Béress, L.; Möller, C.; Marí, F.; Forssmann, W.-G.; Tytgat, J. (2013). Sea anemone toxins: insecticides and painkillers of the future?, in: Mees, J. et al. (Ed.) Marine biotechnology in the European research area: Challenges and opportunities for Europe. Final CSA MarineBiotech Conference. Royal Flemish Academy of Belgium for Science and the Arts, Brussels, Belgium, 11-12 March 2013. VLIZ Special Publication, 64: pp. 7, more Tytgat, J. (2009). Expectancies of a toxicologist: from sudden poisoning to miraculous discovery, in: Mees, J. et al. (Ed.) VLIZ Young Scientists' Day, Brugge, Belgium 6 March 2009: book of abstracts. VLIZ Special Publication, 41: pp. 14, more
Reports (2) [show]
De Raedemaecker, F.; Sandra, M.; Goeminne, G.; Tytgat, J.; Coenye, T.; Devriese, L.; Bicalho, K.; Vandersyppe, S.; Desmet, S.; Bernaerts, H.; Peigneur, S.; Van Vlieberghe, W.; Loosvelt , L. (2022). Final report. D5.1. PROspection for BIOactive compounds in the North Sea. D 5.1. Flanders Marine Institute (VLIZ): Oostende. , more Tytgat, J. (2007). Toxins from jellyfish and sea anemones: a 'sea' of molecules with therapeutic potential. KU Leuven, Laboratorium Toxicologie: Leuven. 23 pp., more
Other publications (2) [show]
De Raedemaecker, F.; Sandra, M.; Devriese, L.I.; Goeminne, G.; Bicalho, K.; Montoye, T.; Tytgat, J.; Bernaerts, H.; Loosvelt , L. (2021). PROspectionfor BIOactivecompounds in the North Sea (PROBIO): creating a knowledge base for blue biotech innovation in Flanders. Poster submited at VLIZ Marine Science Day, Online event 3 March 2021. VLIZ/KU Leuven/Universiteit Gent: Oostende. 1 poster pp., more Tytgat, J. (2008). Toxines van kwallen en zeeanemonen (Cnidaria): een ‘zee’ van moleculen geschikt voor de ontwikkeling van nieuwe geneesmiddelen. Prijs Dr. E. Delcroix 2007 - 11 april 2008, Oostende. [S.n.]: [s.l.]. 1 presentation [52 Slides] pp., more
Thesis (co-)promotor [show]
Seldeslachts, A. (2019). Novel α-conotoxin targeting nicotinic acetylcholine receptor as selective pharmacological tool in drug development. Ir Thesis. Katholieke Universiteit Leuven: Leuven. 59 pp., more

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