D-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona
Krasovec, G.; Hozumi, A.; Yoshida, T.; Obita, T.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Mori, H.; Sasakura, Y. (2022). D-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona. Science Advances 8(10): eabn3264. https://dx.doi.org/10.1126/sciadv.abn3264
In: Science Advances. AAAS: New York. ISSN 2375-2548; e-ISSN 2375-2548, more
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| Authors | | Top |
- Krasovec, G.
- Hozumi, A.
- Yoshida, T.
- Obita, T.
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- Hamada, M.
- Shiraishi, A.
- Satake, H.
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- Horie, T.
- Mori, H.
- Sasakura, Y.
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| Abstract |
d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate–type glutamate receptor (NMDAR). d-Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d-serine in mammalian peripheral tissues such as skin have also been described. However, d-serine’s functions in nonmammals are unclear. Here, we characterized d-serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate Ciona. d-Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of d-serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by d-serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of d-amino acid function among metazoans. |
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