Comparative venomics of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus
Pardos-Blas, J.R.; Tenorio, M.J.; Galindo, J.C.G.; Zardoya, R. (2022). Comparative venomics of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus. Mar. Drugs 20(2): 149. https://dx.doi.org/10.3390/md20020149
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
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| Keywords |
Secretory products > Hormones > Insulin
Virroconus ebraeus (Linnaeus, 1758) [WoRMS]; Virroconus judaeus (Bergh, 1895) [WoRMS]
Marine/Coastal |
| Author keywords |
cone snails; conotoxins; venom duct transcriptomes; venom duct proteomes; differential expression; Cerm03; SF-mi2 |
| Authors | | Top |
- Pardos-Blas, J.R.
- Tenorio, M.J.
- Galindo, J.C.G.
- Zardoya, R.
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| Abstract |
he venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared. The most abundant and shared conotoxin precursor superfamilies in both species were M, O1, and O2. Additionally, three new putative conotoxin precursor superfamilies (Virro01-03) with cysteine pattern types VI/VII and XVI were identified. The most expressed conotoxin precursor superfamilies were SF-mi2 and M in V. ebraeus, and Cerm03 and M in V. judaeus. Up to 16 conotoxin precursor superfamilies and hormones were differentially expressed between both species, and clustered into two distinct sets, which could represent adaptations of each species to different diets. Finally, we predicted, with machine learning algorithms, the 3D structure model of selected venom proteins including the differentially expressed Cerm03 and SF-mi2, an insulin type 3, a Gastridium geographus GVIA-like conotoxin, and an ortholog to the Pionoconus magus ω-conotoxin MVIIA (Ziconotide). |
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