Origins and evolution of extreme life span in Pacific Ocean rockfishes
Kolora, S.R.J.; Owens, G.L.; Vazquez, J.M.; Stubbs, A.; Chatla, K.; Jainese, C.; Seeto, K.; McCrea, M.; Sandel, M.W.; Vianna, J.A.; Maslenikov, K.; Bachtrog, D.; Orr, J.W.; Love, M.; Sudmant, P.H. (2021). Origins and evolution of extreme life span in Pacific Ocean rockfishes. Science (Wash.) 374(6569): 842-847. https://dx.doi.org/10.1126/science.abg5332
In: Science (Washington). American Association for the Advancement of Science: New York, N.Y. ISSN 0036-8075; e-ISSN 1095-9203, more
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| Keywords |
Sebastes aleutianus (Jordan & Evermann, 1898) [WoRMS]; Sebastes minor Barsukov, 1972 [WoRMS]
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| Authors | | Top |
- Kolora, S.R.J.
- Owens, G.L.
- Vazquez, J.M.
- Stubbs, A.
- Chatla, K.
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- Jainese, C.
- Seeto, K.
- McCrea, M.
- Sandel, M.W.
- Vianna, J.A.
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- Maslenikov, K.
- Bachtrog, D.
- Orr, J.W.
- Love, M.
- Sudmant, P.H.
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| Abstract |
Pacific Ocean rockfishes (genus Sebastes) exhibit extreme variation in life span, with some species being among the most long-lived extant vertebrates. We de novo assembled the genomes of 88 rockfish species and from these identified repeated signatures of positive selection in DNA repair pathways in long-lived taxa and 137 longevity-associated genes with direct effects on life span through insulin signaling and with pleiotropic effects through size and environmental adaptations. A genome-wide screen of structural variation reveals copy number expansions in the immune modulatory butyrophilin gene family in long-lived species. The evolution of different rockfish life histories is coupled to genetic diversity and reshapes the mutational spectrum driving segregating CpG→TpG variants in long-lived species. These analyses highlight the genetic innovations that underlie life history trait adaptations and, in turn, how they shape genomic diversity. |
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