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Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice
Johansson, N.; Fredriksson, A.; Eriksson, P. (2008). Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. NeuroToxicology 29(1): 160-169. https://dx.doi.org/10.1016/j.neuro.2007.10.008
In: NeuroToxicology. Elsevier Science: Amsterdam. ISSN 0161-813X; e-ISSN 1872-9711, more
Peer reviewed article  
Available in  Authors 
Author keywords
    PFC PFOS PFOA PFDA Developmental neurotoxicity Behaviour
Authors  Top 
  • Johansson, N.
  • Fredriksson, A.
  • Eriksson, P.
Abstract
    Perfluorinated compounds (PFCs) are found in applications such oil/water repellents for clothing fabrics, carpets, food packaging, lubricants, surfactants and fire extinguishers. PFCs are persistent in the environment. They have been found in humans and in wildlife.

    We reported earlier that persistent organic pollutants (POPs), such as DDT, PCBs and BFRs, caused developmental neurotoxic defects in mice, manifested as persistent aberrations in spontaneous behaviour, habituation capability, learning and memory, and changes in the cholinergic system in adults, when mice were exposed during a critical period of neonatal brain development.