A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe
Yonemitsu, M.A.; Giersch, R.M.; Polo-Prieto, M.; Hammel, M.; Simon, A.; Cremonte, F.; Avilés, F.T.; Merino-Véliz, N.; Burioli, E.A.V.; Muttray, A.F.; Sherry, J.; Reinisch, C.; Baldwin, S.A.; Goff, S.P.; Houssin, M.; Arriagada, G.; Vázquez, N.; Bierne, N.; Metzger, M.J. (2019). A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe. eLIFE 8: e47788. https://dx.doi.org/10.7554/eLife.47788.001
In: eLIFE. eLife Sciences Publications: Cambridge. e-ISSN 2050-084X, more
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| Keywords |
Mytilus chilensis Hupé, 1854 [WoRMS]; Mytilus edulis Linnaeus, 1758 [WoRMS]; Mytilus trossulus A. A. Gould, 1850 [WoRMS]
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| Authors | | Top |
- Yonemitsu, M.A.
- Giersch, R.M.
- Polo-Prieto, M.
- Hammel, M.
- Simon, A.
- Cremonte, F.
- Avilés, F.T.
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- Merino-Véliz, N.
- Burioli, E.A.V.
- Muttray, A.F.
- Sherry, J.
- Reinisch, C.
- Baldwin, S.A.
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- Goff, S.P.
- Houssin, M.
- Arriagada, G.
- Vázquez, N.
- Bierne, N.
- Metzger, M.J.
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| Abstract |
Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Europe). Sequencing alleles from four loci (two nuclear and two mitochondrial) provided evidence of transmissible cancer in both species. Phylogenetic analysis of cancer-associated alleles and analysis of diagnostic SNPs showed that cancers in both species likely arose in a third species of mussel (M. trossulus), but these cancer cells are independent from the previously identified transmissible cancer in M. trossulus from Canada. Unexpectedly, cancers from M. chilensis and M. edulis |
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