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Marine materials: gene delivery
Singh, B.; Maharjan, S.; Choi, Y-J.; Akaike, T.; Cho, C-S. (2015). Marine materials: gene delivery, in: Kim, S.-K. Springer handbook of marine biotechnology. pp. 1217-1227. https://dx.doi.org/10.1007/978-3-642-53971-8_54
In: Kim, S.-K. (2015). Springer handbook of marine biotechnology. Springer-Verlag Berlin Heidelberg: Berlin. ISBN 978-3-642-53970-1. XLVI, 1512 pp. https://dx.doi.org/10.1007/978-3-642-53971-8, more
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  • Singh, B.
  • Maharjan, S.
  • Choi, Y-J.
  • Akaike, T.
  • Cho, C-S.
Abstract
    The hurdle in the gene therapy is a lack of suitable gene carrier although animal virus vectors have been mostly used in vivo and in clinical applications due to their high transfection efficiency. However, there are several problems such as potential infectivity, inflammation, immunogenicity, and complicated production. Therefore, nonviral vectors have been tried as alternatives. Among nonviral vectors, natural cationic polymers have been used as the gene carriers because they are biocompatible, less immunogenic, no-limitation of gene size to deliver, and easily produced with low cost. This review chapter covers the recent development of chitosan, alginate, and pullulan among marine polymeric materials as gene carriers.
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