Double-stranded RNA viral infection of Trichomonas vaginalis and correlation with genetic polymorphism of isolates
Fraga, J.; Rojas, L.; Sariego, I.; Fernández-Calienes, A. (2011). Double-stranded RNA viral infection of Trichomonas vaginalis and correlation with genetic polymorphism of isolates. Exp. Parasitol. 127(2): 593-599. https://dx.doi.org/10.1016/j.exppara.2010.09.005
In: Experimental parasitology. Academic Press: New York. ISSN 0014-4894; e-ISSN 1090-2449, more
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| Author keywords |
Trichomonas vaginalis virus, RAPD, Polymorphism, TVV |
| Authors | | Top |
- Fraga, J.
- Rojas, L.
- Sariego, I.
- Fernández-Calienes, A.
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| Abstract |
Trichomonas vaginalis can be infected with double-stranded RNA (dsRNA) viruses known as T. vaginalis virus (TVV). This viral infection may have important implications for trichomonal virulence and disease pathogenesis. The objective of this study was to determine the possible correlation between the T. vaginalis genetic polymorphism and the isolate infection with TVV. The Random Amplified Polymorphic DNA (RAPD) technique was used to determine genetic differences among 37 isolates of T. vaginalis using a panel of 30 random primers and these genetic data were correlated with the infection of isolates with TVV. The trees drawn based on RAPD data showed significantly association with the presence of TVV (P = 0.028) demonstrating the existence of concordance between the genetic relatedness and the presence of TVV in T. vaginalis isolates. This result could point to a predisposition of T. vaginalis for the viral enters and/or survival. |
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