Ultra-performance liquid chromatography for the determination of pesticide residues in foods by tandem quadrupole mass spectrometry with polarity switching
Leandro, C.C.; Hancock, P.; Fussell, R.J.; Keely, B.J. (2007). Ultra-performance liquid chromatography for the determination of pesticide residues in foods by tandem quadrupole mass spectrometry with polarity switching. J. Chromatogr. 1144(2): 161-169. https://dx.doi.org/10.1016/j.chroma.2007.01.030
In: Journal of Chromatography A. Elsevier: Amsterdam. ISSN 0021-9673; e-ISSN 1873-3778, more
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| Author keywords |
Ultra-performance liquid chromatography; Tandem mass spectrometry; Polarity switching; Pesticide residues |
| Authors | | Top |
- Leandro, C.C., more
- Hancock, P.
- Fussell, R.J.
- Keely, B.J.
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| Abstract |
An ultra-performance liquid chromatographic (UPLC) electrospray ionisation tandem quadrupole mass spectrometric method has been developed for the determination of 52 pesticides in cereal-based baby foods, oranges and potatoes. The fast polarity switching capability of the mass spectrometer used enabled the determination of 44 of the compounds in the positive ionisation mode and 8 of the compounds in the negative ionisation mode in a single run. Prior to analysis, co-extractives were removed from acetonitrile extracts using dispersive solid-phase extraction with primary secondary amine (50 mg). The UPLC method separates all of the pesticides, resolves structural isomers (e.g. butocarboxim sulfoxide and aldicarb sulfoxide) and has a short (7 min) cycle time. Extracts spiked with pesticides at 0.10 and 0.01 mg kg-1 yielded average recoveries in the range of 66–124% with relative standard deviations less than 19% for the majority of the analytes. |
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