University of Antwerp; Faculteit Farmaceutische, Biomedische en Diergeneeskundige Wetenschappen; Departement Biomedische Wetenschappen (BMW), more
Function: President
Direct contact at institute:
Tel.: +32-(0)3-820 23 35
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| A1 Publications (7) [show] |
- Kopljar, I.; Grottesi, A.; de Block, T.; Rainier, J.D.; Tytgat, J.; Labro, A.J.; Snyders, D.J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology 107: 160-167. https://dx.doi.org/10.1016/j.neuropharm.2016.03.010, more
- Martínez-Morales, E.; Kopljar, I.; Rainier, J.D.; Tytgat, J.; Snyders, D.J.; Labro, A.J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon 120: 57-60. https://dx.doi.org/10.1016/j.toxicon.2016.07.017, more
- Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.; Tytgat, J.; Snyders, D.J. (2013). The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. J. Gen. Physiol. 141(3): 359-369. https://dx.doi.org/10.1085/jgp.201210890, more
- Stas, J.; Kopljar, I.; Labro, A.; Peigneur, S.; Zaharenko, A.J.; Tytgat, J.; Snyders, D.J. (2013). A gating modulator peptide toxin for Shaker-type Kv1 channels derived from the sea anemone Bunodosoma cangicum. Biophys. J. 104(2): 125A-125A, more
- Kopljar, I.; Labro, A.J.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2012). Voltage sensor trapping in voltage-gated K-channels by the marine neurotoxin Gambierol. Toxicon 60(2): 150-151. dx.doi.org/10.1016/j.toxicon.2012.04.111, more
 Kopljar, I.; Labro, A.J.; Cuypers, E.; Johnson, H.W.B.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. (2009). A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc. Natl. Acad. Sci. U.S.A. 106(24): 9896-9901. http://dx.doi.org/10.1073/pnas.0812471106, more- Cuypers, E.; Abdel-Mottaleb, Y.; Kopljar, I.; Rainier, J.; Raes, A.L.; Snyders, D.J.; Tytgat, J. (2008). Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon 51(6): 974-983. https://dx.doi.org/10.1016/j.toxicon.2008.01.004, more
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| Book chapter [show] |
- Kopljar, I.; Peigneur, S.; Snyders, D.J.; Tytgat, J. (2014). The mechanism of action of microalgal toxins interacting with Nav and Kv channels, in: Rossini, G.P. (Ed.) Toxins and biologically active compounds from microalgae: Volume 2. Biological effects and risk management. pp. 3-34, more
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