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5-Hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios
Salmoun, M.; Devijver, C.; Daloze, D.; Braekman, J.C.; Van Soest, R.W.M. (2002). 5-Hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios. J. Nat. Prod. 65(8): 1173-1176. dx.doi.org/10.1021/np020009+
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
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  • Salmoun, M.
  • Devijver, C.
  • Daloze, D.
  • Braekman, J.C., meer
  • Van Soest, R.W.M., meer

Abstract
    Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatus were found to contain 5-hydroxytryptamine-derived alkaloids. Their structures were determined on the basis of their spectral properties. H. erectus contained hyrtiosulawesine (4), a new β-carboline alkaloid, together with the already known alkaloids 5-hydroxyindole-3-carbaldehyde (1), hyrtiosin B (2), and 5-hydroxy-3-(2-hydroxyethyl)indole (3). H. reticulatus contained the novel derivative 1,6-dihydroxy-1,2,3,4-tetrahydro-β-carboline (11) together with serotonin (5), 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline (7), and 6-hydroxy-3,4-dihydro-1-oxo-β-carboline (9).

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