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Peripheral-type benzodiazepine receptor (PBR) is a target of environmental hazards affecting the hormone regulation of testicular steroidogenesis
Boujrad, N.; Papadopoulos, V. (2000). Peripheral-type benzodiazepine receptor (PBR) is a target of environmental hazards affecting the hormone regulation of testicular steroidogenesis, in: Norberg, B. et al. (Ed.) Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. pp. 208
In: Norberg, B. et al. (2000). Proceedings of the 6th International Symposium on the Reproductive Physiology of Fish, Bergen, Norway, July 4-9, 1999. International Symposium on the Reproductive Physiology of Fish, 6. Department of Fisheries and Marine Biology, University of Bergen: Bergen. ISBN 82-7461-048-2. 499 pp., meer
In: International Symposium on the Reproductive Physiology of Fish. Museo Nacional de Ciencias Naturales. , meer
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  • Boujrad, N.
  • Papadopoulos, V.
Abstract
    We have shown that PBR is a key element in the acute hormone regulation of steroidogenesis in Mammals. The objective of this study was to determine the in vitro anti-androgenic effects of the xenobiotic, the perflurodecanoic acid (PFDA) peroxisome proliferators, on the mouse tumor Leydig cells MA-10 steroidogenesis. Our results show that: the endocrine disrupter PFDA suppress in time- and dose-dependent manner the hCG-stimulated progesterone biosynthesis by MA-10, and PFDA affected the transfer of cholesterol to the inner mitochondria membrane rather than the P450-scc activity. Image analysis of Western and Northern blot indicates that PFDA induce a significant reduction of PBR mRNA and 18 kDa PBR protein. These data show that the inhibitory effect of PFDA on steroidogenesis is localized at the level of the cholesterol transport to the inner mitochondria membrane and is mediated by PBR.
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