The ED-North database is a database containing the data that where gathered during the SPSD I research project 'Evaluation of possible impacts of endocrine disruptors on the North Sea ecosystem'.
This ED-NORTH project aimed at establishing a clear overview of the increasing volume of available scientific literature on endocrine disruption. Specific objectives were: to address the uncertainties presently associated with the issue of environmental endocrine disruption; to specify future research and policy needs; to accomplish these tasks specifically for endocrine modulating activity in the marine environment.
Based on the available scientific literature a list and electronic database of chemicals with (potential) endocrine disruptive activity was developed. This relational database contains information on the hormone disrupting potential, including effects and physico-chemical properties of these chemicals. Chemicals of which enough data was available on the environmental concentrations in the North Sea and the sources and endocrine effects they cause were prioritised. Finally, future research and policy needs were formulated based on these results.
The ED-North database is a MS Access relational database that contains 423 references, 765 chemical compounds and 2355 test cases. A search interface to this database provides the possibility to search on chemical compound, described effect and author. An entire list of compounds can be obtained by leaving the search fields blank.
| 15-a-OH | 15-a-hydroxylase |
| 17,20-b-P | 17,20-b-dihydroxy-4-pregnen-3-one
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| 17-BHD | 17-b-hydroxydehydrogenase
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| 20-b-S | 17,20b,21-Trihydroxy-4-pregen-3-one
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| 3-BHD | 3-b-hydroxydehydrogenase
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| 5-HT | Serotonin
|
| 6-a-OH | 6-a-hydroxylase
|
| a.i. | Active ingredient
|
| ABG | Androgen binding globulin
|
| ABP | Androgen binding protein
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| ACTH | Adrenocorticotrophic hormone
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| AGD | Anogenital distance
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| AhR | Arylhydrocarbon receptor
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| ALH | Amplitude of lateral head displacement (of sperm)
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| AR | Androgen receptor
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| BrdU | 5-Bromodeoxyuridine
|
| CAF | Chorioallantoic fluid
|
| cAMP | Cyclic adenosine 3'5'-monophosphate
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| CF | Condition factor
|
| ChE | Choline esterase
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| CMP | Cypris major protein
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| CoMFA | Comparative molecular field analysis
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| CR | Cortisol receptor
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| CYP450 | Cytochrome P450
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| DbH | Dopamine b-hydroxylase
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| DES | Diethylstilbestrol
|
| DHT | Dihydrotestosteron |
| EC100 | Effect concentration for 100% of the organisms exposed
|
| EC50 | Effect concentration for 50% of the organisms exposed
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| EEQ | 17b-estradiol equivalent concentration
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| ER | Estrogen receptor
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| EROD | Ethoxyresorufin o-deethylase
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| FOM | Final oocyte maturation
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| FSH | Follicle stimulating hormone
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| G6PD | Glucose-6-phosphate dehydrogenase
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| GAM | Gonadal-adrenal mesonephros
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| GnRH | Gonadotropin releasing hormone
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| GR | Glucocorticoid receptor
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| GSI | Gonado somatic index (gonadal weight/total body weight)
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| GTH | Gonadotropin
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| GVBD | Germinal vesicle breakdown
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| hAR | Human androgen receptor
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| hCG | Human chorionic gonadotropin
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| hER | Human estrogen receptor
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| hPR | Human progesterone receptor
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| HSI | Hepatosomatic index (weight liver/total body weight)
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| IC | Inhibition concentration
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| IC50 | Inhibition concentration for 50% of the organisms exposed
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| Ki | Inhibition constant
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| LA/BC | Levator ani/bulbocavernosus
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| LF | Lactoferrin
|
| LH | Luteinizing hormone
|
| LOAEL | Lowest observed adverse effect level
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| LOEC(max) | Lowest concentration which induces maximal effect
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| LOEL | Lowest observed effect level
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| MCF-7 | Estrogen-sensitive human breast cancer cells (E-Screen assay)
|
| ME | Malic enzyme
|
| Meq | Molar equivalents
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| MFO | Mixed function oxygenase
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| mGTH | Mytus gonadotropin
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| mPXR | Mouse pregnane X receptor
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| NAOEL | No adverse observed effect level
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| NE | Norepinephrine
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| NOEL | No observed effect level
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| oLH-RH | Ovine luteinizing hormone releasing hormone
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| PAH | Polycyclic aromatic hydrocarbon
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| PBDE | Polybrominated diphenyl ehter
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| PCB | Polychlorinated biphenyl
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| pC50 | Negative log of the concentration required to displace 50% of bound ligand
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| PEPCK | Phosphoenolpyruvate carboxykinase
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| PGC | Primordial germ cell
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| PKC | Protein kinase C
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| PMS | Pregnant mare serum
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| PMSG | Pregnant mare serum gonadotropin
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| PPR | Ratio of the precloacal length to the posterior lobe of the plastron (sexually dimorphic characteristic)
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| PR | Progesterone receptor
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| PRL | Prolactin
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| PROD | Pentoxyresorufin o-deethylase
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| PXR | Pregnane X receptor
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| QSAR | Quantitative structure-activity relationship
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| RAR | Retinoic acid receptor
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| RBA | Relative binding affinity
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| RTA | Relative transactivation activity
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| rhER | Recombinant human estrogen receptor
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| RPE | Relative proliferative effect compared to 17b-estradiol
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| rtER | Rainbow trout estrogen receptor
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| SAT | Sex accessory tissue
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| SDN-POA | Sexually dimorphic nucleus of the preoptic area
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| SHBG | Sex hormone binding globulin
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| T3 | 3,3',5-Triiodothyronine
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| T4 | Thyroxine
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| TBT | Tributyltin
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| TCDD | 2,3,7,8-Tetrachlorodibenzo-p-dioxin
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| TEQ | TCDD toxic equivalent
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| TH | Tyrosine hydroxulase
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| TP | Testosterone propionate
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| TR | Thyroid receptor
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| TSD | Temperature-dependent sex determinantion
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| TSH | Thyroid stimulating hormone (Thyrotropin)
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| Vt | Vitellin |
| VTG | Vitellogenin
|
