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Enhanced disease resistance in Artemia by application of commercial beta-glucans sources and chitin in a gnotobiotic Artemia challenge test
Soltanian, S.; Francois, J.M.; Dhont, J.; Arnouts, S.; Sorgeloos, P.; Bossier, P. (2007). Enhanced disease resistance in Artemia by application of commercial beta-glucans sources and chitin in a gnotobiotic Artemia challenge test. Fish Shellfish Immunol. 23(6): 1304-1314. dx.doi.org/10.1016/j.fsi.2007.07.004
In: Fish & Shellfish Immunology. Academic Press: London; New York. ISSN 1050-4648; e-ISSN 1095-9947, meer
Peer reviewed article  

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Trefwoorden
    Artemia Leach, 1819 [WoRMS]; Vibrio Pacini, 1854 [WoRMS]
Author keywords
    Artemia; gnotobiotic culture; disease resistance; beta-glucan; Vibrio

Auteurs  Top 
  • Soltanian, S., meer
  • Francois, J.M.
  • Dhont, J., meer
  • Arnouts, S.
  • Sorgeloos, P., meer
  • Bossier, P., meer

Abstract
    The anti-infectious potential of a selection of putative immunostimulants including six commercial beta-glucans (all extracted from baker's yeast Saccharomyces cerevisiae except for Laminarin) and chitin particles were verified in Artemia nauplii by challenging them under gnotobiotic conditions with the pathogen Vibrio campbellii. Under the described experimental conditions, no differential macroscopic nutritional effect (e.g. growth) was observed among the products. Significant increased survival was observed with beta-glucan (Sigma) and Zymosan and to a lesser extent with MacroGard in challenged nauplii. A poor correlation was found between survival values of the challenged Artemia and the product compositions (such as chitin, mannose and beta-glucan content) indicating that the quality of beta-glucans (e.g. the ratio of beta-1,3 and beta-1,6 glucan, the molecular weight, the dimensional structure, type and frequency of branches), eventually in combination with other unidentified compounds, is more important than the amount of product offered. This small-scale testing under gnotobiotic conditions using freshly hatched Artemia nauplii allows for a rapid and simultaneous screening of anti-infectious and/or putative immunostimulatory polymers, and should be combined with studies on cellular and humoral immune responses in order to gain more quantitative insight into their functional properties.

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